I will do consignment in only one place -- the art center in a nearby town. It's a win-win for the center and for me. They get unique "limited edition" or one-of-a-kind handmade pieces that aren't for sale anywhere else, and I get an outlet for my creative juices.
The art center is very good about taking care of their consigned goods, and I am close enough that I can keep an eye on things as well. The center does a 75:25 split or 60:40 split, depending on whether the artist helps out by working for the center 20 hours per season or not.
I did consignment in a couple of other places years ago, and got taught some hard lessons. The other posters are correct in that shop owner may not take good care of your product, since the shop does not own it. It can also be hard to get paid promptly -- there is not a lot of incentive for a struggling or lazy shop owner to send a check for goods sold. I have also had product that just "disappeared", and the shop owner did not pay me for the "lost" product at all.
If you do not deeply trust the shop owner and staff AND cannot personally and regularly check on your stuff (under the guise of "in the neighborhood -- just visiting!"), there is, IMO, far too much risk to consignment sales.