From the research that I've read, a high iodine number seems to contribute to DOS. I keep my iodine under 70 and haven't had any troubles. But other things contribute to DOS as well. However, if you put a 100% olive oil soap in SoapCalc, there that number goes to 85. So it's just tricky if you ask me!
I personally like to see cleansing numbers under 15. And conditioning at least up in the 60's somewhere. But your super fat is going to affect that cleansing as well. Take a salt bar for example: high %'s of coconut is used, but it's countered by a high super fat. It works in that situation though. I'm not sure I'd just have a high cleansing number and high super fat in a regular bar of soap. That's me though.
For lather, there are also so many factors to consider, even the water a person has when it comes to lather. I can have a bubbly factor of 22 in my soap and it bubbles like crazy for me, but I take it to my parents house and it's just down right lame. They have super hard well water. Some people like big, popping bubbles and other like a more lotion-like lather. You can also had sugar to help with the bubbles. 1 TBSP ppo diluted in your water before adding lye.
So really, it's just a ton of trial and error. It really is! Check those numbers on your soaps that you love, compare the differences in numbers, etc.